ISPH Investigator Hongbin Zhang awarded NIH R21 grant

March 3, 2020

ISPH Investigator and CUNY SPH Assistant Professor Hongbin Zhang was awarded an R21 grant from the National Institutes of Health to work with the New York City Department of Health and Mental Hygiene (DOHMH) developing a change-point model on the timing of anti-retroviral treatment (ART) initiation after HIV diagnosis.

The primary goal of public health efforts to control HIV epidemics is to diagnose and treat people as soon as possible after infection. The timing of the first ART treatment after HIV diagnosis is therefore an important population-level indicator of the effectiveness of HIV care programs and policies at local and national levels. However, there are no population-based estimates of the timeliness of ART initiation in the US because data on the timing of ART initiation cannot feasibly and efficiently be collected as part of routine jurisdictional HIV surveillance activities.

Zhang and team will develop a statistical model for the estimation of the timing of ART initiation following HIV diagnosis using routinely collected, population-based data on laboratory tests from all persons diagnosed with HIV infection from the DOHMH. The model will be validated with antiretroviral therapy prescription information, and the methods will be disseminated through a free software package for use by health departments, public health practitioners, and policymakers. The method and software will be strategically important in influencing policies and programs to expand access to HIV prevention and treatment services and to monitor and inform the ending of HIV epidemics at the local and national level.

The proposal’s initial efforts were supported by Dean Ayman El-Mohandes’ Mentored Research Grant with Distinguished Professor and ISPH Executive Director Denis Nash as mentor, now a co-investigator on the project, together with Associate Professor Levi Waldron who will provide insights on R package development. The study was motived by a pioneer work led by Dr. Sarah Braunstein at the DOHMH. Zhang will extend the work by bringing in statistical thinking and new statistical methods.

“It is quite exciting,” Zhang says of the opportunity. “The change point based methods we are going to develop will use longitudinal viral load data to optimize the estimation of ART initiation timing by detecting a time point that induces a change to the underlying biological process.”

About the Institute for Implementation Science in Population Health at the City University of New York
The CUNY Institute for Implementation Science in Population Health (ISPH) was founded on the notion that substantial improvements in population health can be efficiently achieved through better implementation of existing strategies, policies, and interventions across multiple sectors. We study how to translate and scale-up evidence-based interventions and policies within clinical and community settings in order to improve population health and reduce health disparities. CUNY ISPH. Pursuing population health gains through better implementation. Follow us on Twitter: @CUNYISPH.

About the CUNY Graduate School of Public Health and Health Policy
The CUNY Graduate School of Public Health and Health Policy (CUNY SPH) is committed to teaching, research and service that creates a healthier New York City and helps promote equitable, efficient and evidence-based solutions to pressing health problems facing cities around the world. For more information, visit

Published with permission from the original.

Hongbin Zhang