A growing epidemic of stimulant use among men living with HIV could interfere with achievement of the U.S. Ending the HIV Epidemic goals, with improved HIV virologic suppression among this population needed. This project will first examine multi-level determinants of HIV virologic suppression, including stimulant use, in a digitally recruited cohort of men living with HIV. We will then perform a randomized controlled trial of reSTART, a multi-component HIV antiretroviral therapy adherence intervention that combines a point-of-care urine test for HIV adherence self-monitoring and an evidence-based intervention for men living with HIV who use stimulants, to examine reSTART’s impact on virologic suppression, stimulant use, and cost.