The project proposes to set up a longitudinal, community-based research cohort of 3,000 adults in Port-au- Prince, Haiti, to 1) study the prevalence and incidence of selected risk factors for cardiovascular disease, 2) examine the associations between such risk factors and their social and environmental determinants, and 3) record the occurrence of cardiovascular events. In addition to traditional cardiovascular risk factors such as hypertension, obesity, and diabetes, the study will also assess less commonly examined factors such as lead levels, and will collect oral microbiome data for future exploration in relation to cardiovascular risk.