The Haiti Demographic and Health Project aims to describe the population structure, mortality and morbidity patterns, including prevalence of select communicable and non-communicable disease (NCDs) symptoms and their risk factors, in urban slum populations in Port-au-Prince, Haiti. To this end, exhaustive surveys are being conducted with 550 randomly selected households and 1,100 adults. The study is unique due to its combination of population-representative design, emphasis on NCDs, and systematic measurement of blood pressure in an understudied, largely healthcare-naïve, urban slum population in Haiti. Study results will help identify health needs and promising interventions for rapidly evolving slums settings, as well as serve as the foundation of extramural interdisciplinary research proposals on NCD determinants and interventions. The study is led by investigators from Weill Cornell Medical College Center for Global Health, CUNY ISPH, the University of Minnesota, and the GHESKIO clinic in Port-au-Prince, the largest HIV and TB care center in the Caribbean.