This study aims to assess the effectiveness of the NYC Ryan White comprehensive HIV Care Coordination Program (CCP) relative to that of usual care outside the CCP for persons living with HIV and residing in NYC, to determine what individual and program-level factors are associated with optimal care outcomes for CCP participants and to determine the cost-effectiveness of the CCP relative to usual care outside the CCP. Through this work, CHORDS is generating much-needed evidence related to the effectiveness, outcome determinants and cost-effectiveness of a promising, scalable service delivery strategy, ultimately increasing the capacity of HIV care programs to achieve the greatest possible uptake and impact. The project is a collaboration between the CUNY ISPH, the New York City Department of Health and Mental Hygiene, and New York University Section on Value and Effectiveness (SOLVE).